Nature Genetics publishes the very highest quality research in genetics. It encompasses genetic and functional genomic studies on human traits, agricultural.
Large-scale loss-of-function screens and TP53 saturation mutagenesis screens in human cancer cell lines suggest that mutational processes combine with phenotypic selection to shape the landscape of somatic mutations at the TP53 locus. Giacomelli., Xiaoping Yang., Robert E.
Lintner., James M. McFarland., Marc Duby., Jaegil Kim., Thomas P. Howard., David Y.
Takeda., Seav Huong Ly., Eejung Kim., Hugh S. Gannon., Brian Hurhula., Ted Sharpe., Amy Goodale., Briana Fritchman., Scott Steelman., Francisca Vazquez., Aviad Tsherniak., Andrew J. Aguirre., John G. Doench., Federica Piccioni., Charles W.
Roberts., Matthew Meyerson., Gad Getz., Cory M. Johannessen., David E.
Root. & William C. Analyses of 3,514 whole-genome-sequenced individuals from Sardinia indicate that within-island substructure and sex-biased processes have impacted the genetic history of Sardinia, providing new insight into the demography of ancestral Sardinians. Charleston W. Chiang., Joseph H. Marcus., Carlo Sidore., Arjun Biddanda., Hussein Al-Asadi., Magdalena Zoledziewska., Maristella Pitzalis., Fabio Busonero., Andrea Maschio., Giorgio Pistis., Maristella Steri., Andrea Angius., Kirk E. Lohmueller., Goncalo R.
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Abecasis., David Schlessinger., Francesco Cucca. & John Novembre.